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Research Overview: Astym® therapy


Astym® therapy: scientific and clinical research


Background:

Research on Astym therapy began with a multi-disciplinary research team theorizing about a potential physical treatment method with the ability to regenerate and remodel soft tissues. These theories were built upon emerging evidence regarding the degenerative nature of tendinopathy, and the investigations into how cellular mediators and growth factors may enhance healing. Hypothesizing that an external, non-invasive intervention could impact cellular activity, basic science studies were conducted on Astym treatment1,2 to elucidate physiologically relevant mechanisms, and to develop specific treatment protocols aimed at stimulating the regeneration of soft tissues and the resorption of inappropriate scar tissue/fibrosis. Specific protocols were developed defining the use of hand-held instrumentation to topically locate underlying dysfunctional soft tissue and then transfer particular pressures and shear forces to the dysfunctional tissue.
In vivo studies revealed that the Astym protocols improve tendon repair, increased limb function, and normalized movement patterns in animal models.1,2 Further, Astym treatment results in a significant increase in both fibroblast activation and fibroblast number, as well as the production of fibronectin, which together with interstitial collagens may interact to form a fibrillar component of the extracellular matrix.1,2 The increase in fibronection is notable in that fibronectin is thought to be required for normal collagen organization and deposition by fibroblasts and they have the potential to guide cell and tissue behavior during healing as a function of their unique mechanical and bioactive properties.3,4 This preparatory line of basic science research substantiated the cellular impact of Astym treatment and refined the protocols to be used clinically.
In addition to the intended regenerative effects and cellular impact, the standardized Astym therapy process contains: (i) the assessment and treatment of the entire kinetic chain to address improper movement patterns; and (ii) functional exercise programs which include stretching and strengthening to properly load the tissues along longitudinal lines in order to promote healthy, functional alignment of new collagen deposition, and also to address the need for mechanical loading to extend and enhance regenerative properties of growth factors as shown in animal models.5,6,7


Evidence of Effectiveness of Astym Therapy:

Astym therapy has been found to reduce pain and increase function in cases where scar tissue is interfering with movement or causing pain.6,8,9,13 Scar tissue may result from overuse, problematic biomechanics, trauma or surgery. Although Astym therapy routinely demonstrates success in the treatment of conditions where scar tissue is present, dramatic improvement has been shown when Astym therapy is used post-surgically. In a large study of post-surgical TKA patients suffering from persistent knee stiffness, patients who underwent Astym treatment reported significant mean improvements in both Knee Society objective (80 vs. 57 points; p < 0.0001) and functional scores (80 vs. 54 points; p = 0.0003).10 The mean flexion deficit improved significantly (p < 0.001) in all patients after Astym therapy. The mean flexion contracture improved significantly (p = 0.001) in 91% of patients after Astym therapy.10 These dramatic improvements were achieved despite the fact that the subject patients had already failed standard rehabilitation intervention. Another, larger study demonstrated how Astym therapy is able to significantly reduce arthrofibrosis and the need for manipulation under anesthesia (MUA) in the post-surgical TKA population.11 A third study of post-surgical TKA patients confirmed that Astym therapy contributed to optimal range of motion and significantly reduced the need for repeat MUA.12 All these studies show Astym therapy to be highly effective and safe in post-surgical treatment. In this difficult patient population, these results are quite significant.
Specific Astym treatment protocols have been developed for post-mastectomy patients with restricted movement, and the efficacy of those protocols have been demonstrated in clinical studies. Following a course of treatment with Astym therapy, which includes treatment application to the thickened scar tissue and hypersensitive soft tissue adhesions in the affected area, patients experience less pain, increased function and reduced hypersensitivity.6,13 Shoulder range of motion was improved with clinically significant and meaningful change in both flexion and abduction.13
Astym treatment has also been used to assess and successfully treat tendinopathy, and has been found to reduce pain, and increase motion and functional ability.11,12,13,19 When Astym treatment was compared to deep transverse friction massage (DTFM), exercise and stretching in a prospective, randomized, controlled trial design, Astym treatment showed superior efficacy in the resolution of tendinopathy, and further demonstrated efficacy in the cases of tendinopathy that were recalcitrant to DTFM, exercise and stretching.14
In a large, randomized trial on Astym therapy vs. eccentric exercise in the treatment of lateral elbow tendinopathy, Astym treatment resolved 78.3% of subjects with tendinopathy of the lateral elbow, and eccentric exercise resolved 40.9% of subjects. Interestingly, of the recalcitrant subjects who did not resolve with eccentric exercise and then chose to receive Astym treatment, four weeks of Astym application resulted in a resolution of 95.7% (20/21) of subjects, who showed significant improvements in pain with activity (p˂0.005), function (p = 0.002), and DASH scores (p<0.005). Long-term follow-up at 6 and 12 months revealed subjects maintained their gains.15
A randomized, controlled clinical trial on insertional Achilles tendinopathy demonstrated that Astym therapy yielded superior results within a 12-week period, and those superior results were maintained at 26 weeks and 52 weeks.19 The long-term improvement achieved with Astym therapy is important, as various interventions may have effect in the short term, but are unable to achieve positive results in the long-term.
The positive neural effects of Astym therapy have been demonstrated in a large, three-arm randomized trial, which showed that Astym therapy improves muscle performance.20 In this trial, Astym therapy immediately improved muscle performance (maximal force output) for patients presenting with muscular weakness caused by an injury. Subjects that received Astym therapy increased maximal force output of the lower extremity immediately following treatment by an average of 15% from pre-treatment values. This was significantly greater (p < 0.01) than the average 1% and 6% decrease in maximal force output (Newtons) demonstrated in the control and placebo treatment groups, respectively. The results from this RCT indicate positive neural effects from Astym therapy, and are supported by other clinical study indicating improvement in neural conditions such as carpal tunnel syndrome21, restricted movement due to cerebral palsy22 and brain injury.23
It is notable that the positive results on muscle strength from Astym therapy are not shared by some other common approaches. Decreases in muscle strength have been shown to result from various forms of massage24-26 and soft tissue mobilization using devices such as “the Stick”27 and foam rollers.26,27 The beneficial neural effects of Astym therapy have also been shown in the treatment of cerebral palsy. Astym therapy led to significant gains in flexibility, functional strength, and discontinued use of ankle-foot orthotic devices, resulting in improved gait pattern with even stride length and diminished genu recurvatum, decreased pain with standing and walking, and improved activity tolerance.22
In recent years, it has been recommended that observational research be utilized in order to supplement randomized, controlled clinical trials. Observational study can be used to evaluate the impact of therapies in the real world, and many believe it is essential to translate the findings from RCTs into clinical practice. Consistent with these recommendations, outcomes data on Astym therapy has been collected and analyzed on almost 10,000 patients who received Astym therapy. Astym therapy was delivered by over a thousand different clinicians, across multiple sites and in various settings (including outpatient therapy clinics, hospitals, in the military, within industry and in the workplace), and the extensive outcomes data collected is consistent with the results shown in the RCTs on Astym therapy. According to a recent Cochrane Review, on average, there is little difference between the results obtained from quality RCTs and observational studies.28 Following this principle, the consistency between the RCTs on Astym therapy and the extensive outcomes data on Astym therapy, supports the quality of both.
The extensive outcomes data on Astym therapy show the actual response rates, and include data such as response for each diagnosis, patient type, and how co-morbidities impact the response.

This database shows:

  • Expected resolution rates and time frames, which guide routine clinical practice with valuable benchmark data, 
  • Astym therapy is highly effective and safe across a large population
  • The heterogeneity and generalizability of Astym treatment
  • Clinical research findings translate into real world results
  • Results similar to FOTO data, indicating superior effectiveness when compared with other interventions.

In addition to the research outlined above, findings of case studies and case series performed on Astym therapy indicate effectiveness and safety of Astym therapy when applied to other neuromusculoskeletal conditions. For a full listing of research publications, please visit the Research Page of the Astym therapy website.

 

Resources:

1Davidson CJ, Ganion LR, Gehlsen GM, Verhoestra B, Roepke JE, Sevier TL. Rat tendon morphologic and functional changes resulting from soft tissue mobilization. Med Sci Sports Exerc. 1997;29(3):313-9.
2Gehlsen GM, Ganion LR, Helfst R. Fibroblast responses to variation in soft tissue mobilization pressure. Med. Sci. Sports Exerc. 1999;31(4):531-5.
3Branford OA, Brown RA, McGrouther DA, Grobbelaar AO, Mudera V. Shear-aggregated fibronectin with anti-adhesive properties. J Tissue Eng Regen Med. 2011;5(1):20-31.
4McDonald JA, Kelley DG, Broekelmann TJ. Role of fibronectin in collagen deposition: Fab' to the gelatin-binding domain of fibronectin inhibits both fibronectin and collagen organization in fibroblast extracellular matrix. J Cell Biol. 1982;92(2):485-92.
5Virchenko O, Aspenberg P. How can one platelet injection after tendon injury lead to a stronger tendon after 4 weeks? Interplay between early regeneration and mechanical stimulation. Acta Orthop. 2006;77(5):806-12.
6Davies CC, Brockopp DY. Use of ASTYM® treatment on scar tissue following surgical treatment for breast cancer: a pilot study. Rehabil Oncol. 2010;28(3):3-12.
7McCormack JR. The management of bilateral high hamstring tendinopathy with ASTYM® treatment and eccentric exercise: a case report. J Man Manip Ther. 2012;20(3):142-6.
8Slaven EJ, Mathers J. Management of chronic ankle pain using joint mobilization and Astym® treatment: a case report. Journal of Manual and Manipulative Therapy. 2011;19(2):108-112.
9Melham TJ, Sevier TL, Malnofski MJ, Wilson JK, Helfst RH. Chronic ankle pain and fibrosis successfully treated. Med Sci Sports Exerc. 1998; 30(6): 801-804.
10Chughtai M, Mont MA, Cherian C, Cherian JJ, Elmallah RD, Naziri Q, Harwin SF, Bhave A. A Novel, Nonoperative Treatment Demonstrates Success for Stiff Total Knee Arthroplasty after Failure of Conventional Therapy. J Knee Surg. 2015; [Epub ahead of print] PMID: 26713596
11McGinn T, Chughtai M, Bhave A, Ali O, Mudaliar P, Khlopas A, Harwin SF, Mont MA. Innovative Multi-Modal Physical Therapy Reduces Incidence of Manipulation Under Anesthesia (MUA) in Non-Obese Primary Total Knee Arthroplasty. Surg Technol Int. 2016 Sep 10;XXIX. pii: sti29/764. [Epub ahead of print]
12Chughtai M, McGinn T, Bhave A, Khan S, Vashist M, Khlopas A, Mont MA. Innovative Multimodal Physical Therapy Reduces Incidence of Repeat Manipulation under Anesthesia in Post-Total Knee Arthroplasty Patients Who Had an Initial Manipulation under Anesthesia. J Knee Surg. 2016 Sep 21. [Epub ahead of print]
13Davies CC, Brockopp D, Moe K. Astym therapy improves function and range of motion following mastectomy. Breast cancer: Targets and Therapy 2016:8 39–4.
14McCormack JR. The management of mid-portion Achilles tendinopathy with Astym® and eccentric exercise: a case report. Int J Sports Phys Ther. 2012; 7(6):672-677.
15McCrea EC, George SZ. Outcomes following Astym therapy for patients with knee pain: A case series. Orthopaedic Physical Therapy Practice. 2010;22(2):69-74.
16McCormack JR. The management of bilateral high hamstring tendinopathy with ASTYM® treatment and eccentric exercise: a case report. J Man Manip Ther. 2012; 20(3):142-146
17Wilson JK, Sevier TL, Helfst RH, Honing EW, Thomann AL. Comparison of rehabilitation methods in the treatment of patellar tendinitis. J Sport Rehabil. 2000;9(4):304-314.
18Sevier, TL, Stegink-Jansen CW. Astym® Treatment vs. Eccentric Exercise for Lateral Elbow Tendinopathy: a Randomized Controlled Clinical Trial. PeerJ. 2015: 3:e967; DOI 10.7717/peerj.96.
19McCormack JR, Underwood FB, Slaven EJ, Cappaert TA. Eccentric Exercise Versus Eccentric Exercise and Soft Tissue Treatment (Astym) in the Management of Insertional Achilles Tendinopathy: A Randomized Controlled Trial. Sports Health. 2016 Feb 18. pii: 1941738116631498. [Epub ahead of print].
20Kivlan BR, Carcia CR, Clemente FR, Phelps AL, Martin RL. The effect of Astym® Therapy on muscle strength: a blinded, randomized, clinically controlled trial. BMC Musculoskelet Disord. 2015; 16:325.
21Baker D, Wilson JK. Bilateral carpal tunnel syndrome in a piano teacher. Physical Therapy Case Reports. 1999; 2(2): 73-76.
22Scheer NA, Alstat LR, Van Zant RS. Astym Therapy Improves Bilateral Hamstring Flexibility and Achilles Tendinopathy in a Child with Cerebral Palsy: A Retrospective Case Report. Clinical Medicine Insights: Case Reports 2016:9 95–98 doi: 10.4137/CCRep.S40623.
23Ryan SL, Wallace P. Use of Astym® Treatment to Improve Contractures and Dyskinesia in an Individual with Anoxic Encephalopathy. Combined Sections Meeting, APTA, 2009, Las Vegas, Nevada.
24Arroyo-Morales M, Fernandez-Lao C, Ariza-Garcia A, Toro-Velasco C, Winters M, Diaz-Rodriguez L, et al. Psychophysiological effects of preperformance massage before isokinetic exercise. J Strength Cond Res. 2011;25(2):481–8.
25McKechnie GJ, Young WB, Behm DG. Acute effects of two massage techniques on ankle joint flexibility and power of the plantar flexors. J Sports Sci Med. 2007;6(4):498–504.
26Wiktorsson-Moller M, Öberg B, Ekstrand J, Gillquist J. Effects of warming up, massage, and stretching on range of motion and muscle strength in the lower extremity. Am J Sports Med. 1983;11(4):249–52.
27Mikesky AE, Bahamonde RE, Stanton K, Alvey T, Fitton T. Acute effects of The Stick on strength, power, and flexibility. J Strength Cond Res. 2002;16(3):446–50.
28Anglemyer A, Horvath HT, Bero L. Healthcare outcomes assessed with observational study designs compared with those assessed in randomized trials. Cochrane Database of Systematic Reviews. 2014; Issue 4. Art. No.: MR000034. DOI: 10.1002/14651858.MR000034.pub2.
Is Evidence on Astym therapy applicable to Instrument Assisted Soft Tissue Mobilization (IASTM) or vice versa?
Astym therapy and IASTM are very different in goals and application, and therefore research findings from one would not apply to the other.
What is the research on IASTM techniques?
IASTM techniques
Background:
IASTM is described as “an instrument assisted form of deep transverse friction massage (DTFM) as proposed by Cyriax”.a The goal of IASTM is to mechanically break up scar tissue and fascial restrictions.c,d Tools made of steel or an otherwise rigid material are utilized to induce trauma to the affected soft tissues and initiate an inflammatory response.b,c Applying ice is a standard practice after performing IASTM to help abate excessive inflammation sustained from the treatment.e The amount of trauma or the extent of the inflammatory response are not defined in the limited amount of literature on IASTM, however, anecdotal reports and video documentation of IASTM indicate the trauma may be significant. The questions regarding the safety of IASTMs are also reinforced by cautions issued by the major IASTM tool manufacturer about concerns of IASTM’s safety, “causing therapists and medical doctors to 1) not consider IASTM for their outpatient clinics and 2) specifically rule out Graston Technique® treatment for their patients”.f The safety concerns and questionable effectiveness have resulted in some physicians and physician groups recommending against IASTM application.
Animal studies have shown that transverse frictions do not promote repair of sprained ligaments,g and this apparent inability to heal soft tissue appears to extend to the tooled versions of DTFM (IASTMs). In an animal study where IASTM tools were used to perform cross-fiber massage, it was shown that the potential for initial acceleration of tissue healing did not result in improved overall ligament healing.h
Evidence of Effectiveness of IASTM techniques:
There are some anecdotal reports suggesting that the IASTM techniques may be helpful in soft tissue disorders, however, there is inadequate evidence in the literature to support clinical use. A systematic review published in September 2016 evaluated the research on IASTM and concluded the current research does not support the efficacy of IASTM for treating musculoskeletal pathologies. Recognizing the fact that some clinicians utilize IASTM without supporting research, the systematic review noted there is a gap between the current research and clinical practice. This systematic review did not include Astym therapy, but rather distinguished Astym therapy and acknowledged Astym therapy has its own body of evidence that differs from IASTM.i
In a controlled study with a repeated measures design, patients who were treated with IASTM showed a significant increase in pain and a significant decrease in the perception of function, where the ability to perform activities of daily living decreased following IASTM.j In this 2015 study, the treating clinician had completed the Advanced Upper/Lower Quadrant Training in IASTM, Module 2 (Graston Technique®, Indianapolis, IN), and used this technique in the study.j
In a pilot study where the same clinician used IASTM tools to deliver treatment to one group and then performed the same treatment on another group with only the clinician’s hands, it was found that using tools did not improve clinical results, suggesting that manual therapy with IASTM tools is no more effective than manual therapy with hands alone.k
In a larger study adding IASTM to a dynamic balance training program for chronic ankle instability, it was shown that the addition of IASTM did not improve treatment results of subjects.l
In a study of 30 subjects with lateral elbow tendinopathy, IASTM was compared to no treatment (subjects waiting with information provided on stretching, ergonomics and what to expect with the condition), and it was found that IASTM results were comparable to no treatment being provided.m
Case reports and a case series have been published where IASTM was applied, however, IASTM is typically combined with other approaches, such as chiropractic manipulation, ART, electrical stimulation, ultrasound, exercise and/or acupuncture, making it difficult or impossible to draw conclusions or determine the effectiveness of any one approach. Further study is needed on IASTM to determine if it has any role in the treatment of soft tissue dysfunction. Some weak evidence may suggest that IASTM could assist in temporarily increasing ROM for a short period of time. However, massage has been the traditional approach to accomplish this, and there has been no suggestion that IASTM would provide improved results beyond the traditional means of massage, stretching and exercise.
aMiners AL, Bougie, TL. Chronic Achilles tendinopathy: a case study of treatment incorporating active and passive tissue warm-up, Graston Technique®, ART®, eccentric exercise, and cryotherapy. J Can Chiropr Assoc. 2011;55:269–79.
bPapa JA. Conservative management of Achilles Tendinopathy: a case report. J Can Chiropr Assoc. 2012 Sep;56(3):216-24.
cDaniels CJ, Morrell AP. Chiropractic management of pediatric plantar fasciitis: a case report. J Chiropr Med. 2012 Mar;11(1):58-63.
dSolecki TJ, Herbst EM. Chiropractic management of a postoperative complete anterior cruciate ligament rupture using a multimodal approach: a case report. J Chiropr Med. 2011 Mar;10(1):47-53.
eBayliss AJ1, Klene FJ, Gundeck EL, Loghmani MT. Treatment of a patient with post-natal chronic calf pain utilizing instrument-assisted soft tissue mobilization: a case study. J Man Manip Ther. 2011 Aug;19(3):127-34.
fGraston Technique® Clinical Information for the GT Professional, The Edge, Spring 2011.
gViola L. A critical review of the current conservative therapies for tennis elbow (lateral epicondylitis). Australas Chiropr Osteopathy. 1998 Jul;7(2):53-67.
hLoghmani MT, Warden SJ. Instrument-assisted cross-fiber massage accelerates knee ligament healing. J Orthop Sports Phys Ther. 2009;39:506-14.
iCheatham SW, Lee M, Cain M, Baker R. The efficacy of instrument assisted soft tissue mobilization: a systematic review. J Can Chiropr Assoc. 2016 Sep;60(3):200-211.
jVardiman JP, Siedlik J, Herda T, Hawkins W, Cooper M, Graham ZA, Deckert J, Gallagher P. Instrument-assisted soft tissue mobilization: effects on the properties of human plantar flexors. Int J Sports Med. 2015 Mar;36(3):197-203.
kBurke J, Buchberger DJ, Carey-Loghmani MT, Dougherty PE, Greco DS, Dishman JD. A pilot study comparing two manual therapy interventions for carpal tunnel syndrome. J Manipulative Physiol Ther. 2007;30(1):50-61.
lSchaefer JL, Sandrey MA. Effects of a 4-week dynamic-balance-training program supplemented with graston instrument-assisted soft-tissue mobilization for chronic ankle instability. J Sport Rehabil. 2012 Nov;21(4):313-26.
mBlanchette MA, Normand MC. Augmented soft tissue mobilization vs natural history in the treatment of lateral epicondylitis: a pilot study. J Manipulative Physiol Ther. 2011 Feb;34(2):123-30.


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